Enantioselective organocatalytic hydride reduction.

Enantioselective organocatalytic reductive amination.

The first enantioselective organocatalytic reductive amination reaction has been accomplished. The development of a new chiral phosphoric acid catalyst has provided a convenient strategy for the enantioselective construction of protected primary amines and provided a highly stereoselective method for the reductive amination of heterocyclic amines. A diverse spectrum of ketone and amine substrat...

A highly enantioselective organocatalytic method for reduction of aromatic N-alkyl ketimines.

Organocatalytic transfer hydrogenation of cyclic enones.

The first enantioselective organocatalytic transfer hydrogenation of cyclic enones has been accomplished. The use of iminium catalysis has provided a new organocatalytic strategy for the enantioselective reduction of beta,beta-substituted alpha,beta-unsaturated cycloalkenones, to generate beta-stereogenic cyclic ketones. The use of imidazolidinone 4 as the asymmetric catalyst has been found to ...

The direct and enantioselective organocatalytic alpha-oxidation of aldehydes.

The first direct enantioselective catalytic alpha-oxidation of carbonyls has been accomplished. The use of enamine catalysis has provided a new organocatalytic strategy for the enantioselective oxyamination of aldehydes, to generate alpha-oxyaldehydes, important chiral synthons for natural product and medicinal agent synthesis. The use of l-proline as the asymmetric catalyst has been found to m...

Organocatalytic enantioselective conjugate addition of aldehydes to maleimides.

The highly enantioselective direct organocatalytic conjugate addition of aldehydes to maleimides is presented.